HCV homologs in nature Essay Example | Topics and Well Written Essays - 1750 words

HCV homologs in nature - Essay Example Viruses are one of the microbes that have caused severe harm to human life and health. Out of the whole pool of viruses, is hepatitis C virus that has infected around 3% of the global population. The question of finding a HCV homolog in other animals is essential to probe deeper into its phylogenetic linkage in nature. This review highlights the homolog Hepatitis C Virus in infected dogs termed as Canine Hepatitis C virus, and in healthy horses as well as bats. A whole array of techniques has been discussed in detail employed by the scientists in these discoveries such as nested PCR, RT- PCR as well as microarray techniques. Recently, rodent models have also been reported using these techniques owing to the ease of handling and ethically appropriate. A comparison of the novel viruses reported by different scientists was also compared in order to assess the similarities and differences between these viruses. With such findings at our disposal, scientists can better understand disease mechanisms and thus conduct quality research in disease prevention in terms of vaccine development as well as cure. Viruses have been the ‘danger microbes’ since centuries. The world has suffered great losses in many pandemics such as 1918 flu pandemic targeting roughly around 50 -100 million people which makes 5% of the world population at that time. (Patterson, 1991) (Johnson, 2002). History has witnessed many such disease disasters such as AIDS pandemic in 1981 killing around 25 million people. (Mawar, 2005). With human life so vulnerable to viruses, it is of utmost importance to study the impact of novel viruses on human health. It is now believed that many animal viruses cause two-thirds of infectious diseases in humans. For example, the Nipah, severe acute respiratory syndrome (SARS) and Ebola viruses have been found abundantly in bats in a study conducted by researchers in Columbia University and Eco-health Alliance. During a four-year study from 2006 – 20 10, hundreds of urine and fecal samples of bats were tested for viral sequences. Results showed the prevalence of nine virus families in the samples and discovery of 50 novel viruses (ten of which had similarity with Nipah virus, and was responsible for many outbreaks in South Asia). (Kupperschmidt, 2013) Hsieh et al discovered a novel strain of swine Hepatitis E virus (HEV) in pigs which was thought to be the causal agent in more than 10% non-A, non-B and non-C hepatitis patients in Taiwan. (Hseih, 1999) Thus, it becomes important to study the origin of novel viruses and the extent of danger they pose to human beings. The scope of this paper describes the connection between these viruses and human disease and the techniques used in identification of such viruses. Key Technologies Used Quan et al applied Unbiased High Throughput Sequencing technique for assessment of the serum specimens collected from 415 healthy bats that represented seven families, 26 genera and 33 species in taxo nomic classification; these inhabited five countries - Guatemala, Democratic Republic of China, Nigeria, Cameroon and Kenya. (Quan, 2013) Unbiased High Throughput Screening (UHTS) is one of the best techniques known until now that enable the discovery of novel pathogens. Many novel pathogens have been identified using this technique. Palacios et al reported the discovery of novel arena virus that usually causes mild illness but numerous fatal infections have been identified in patients with solid-organ transplantation. (Palacios, 2008) UHTS provides the advantage that it is unbiased by nature and provides full opportunity to probe the entire tree of life. The protocol of novel pathogen discovery involves amplification and sequencing, raw sequences are assorted into non-redundant sequence sets. Sequences that are unique are assembled into contiguous sequences which are then compared against sequence databases using computational softwares. These softwares match these sequences at nuc leotide and amino

Nike Corporation Case Study Example | Topics and Well Written Essays - 750 words

Nike Corporation - Case Study Example Founded in the year 1972 by a man named Philip Knight who is the co-founder and the Chairman today and by Bill Bowerman both set out with a dream and that has gradually taken the shape of reality. Nike has its head quarters situated in the United States of America and to be more specific it is situated in Beaverton, Oregon. The word Nike has been adapted and taken from the word Nike which was the name of a Greek Goddess of Victory. Nike today has many product lines each of which cater to different sports and sport areas, names such as Nike golf, Nike pro, and Air Jordan are just a few of the lot. And these names are also vastly known as trusted when it comes to the various products that are manufactured and marketed under them. Nike is one company that produces a very widespread range of sports equipment. The first ever products that Nike produced were shoes that could be used as track running shoes and shoes that could be used to play basket ball. Once that started going well they began manufacturing different kinds of sports wear such as jackets and trousers for tennis, football, and cricket etc. Nike belongs to the sportswear and sports equipment manufacturing industry and when it comes to athletic shoes, apparel and other sports equipment it is known to one of the major American suppliers. Nike currently has factories in many countries come of which are China, Taiwan, India, Turkey and Pakistan etc, and to date has about 500 factories working at manufacturing their products. The biggest rivals of Nike currently in the market of sportswear and sports equipment are quite a lot as Nike is seen as a threat to many sports and even some fashion brands but the leading rivals are Reebok which came along in the year 1980. After that the advent of Adidas brought its own level of threat and the rivalry increased for Nike. The board of directors for Nike contains people such as Mark Parker, Timothy D. Cook and Jill Ker Conway. CURRENT SUCCESS STATEGY: The story behind or the reason behind Nike being such a successful company is embedded in its marketing strategies. Besides the advertisement and promotions of its many products there has always been deep focus by the heads of this company on the following details which has lead to it being the leading brand name today. Pricing is one of those details the price of Nike products has always been higher than that pf competitors, its products have always been kept to go with the changing trends and are always upgraded to fit new profiles and the new generation. Placement of sales outlets has been another key detail that has helped. And last but not least the advertisement of its products being shown and made in different times and languages to accommodate their consumers with full understanding and satisfaction guaranteed. That all combined with its catchy brand slogan "just do it" gives the consumer a reliable, trendy and durable product